The Future of Educational Neuroscience     

Kurt W. Fischer  Usha Goswami  John Geake  the Task Force on the Future of Educational Neuroscience 《Mind, Brain, and Education》2010,4(2):68-80

The primary goal of the emerging field of educational neuroscience and the broader movement called Mind, Brain, and Education is to join biology with cognitive science, development, and education so that education can be grounded more solidly in research on learning and teaching. To avoid misdirection, the growing worldwide movement needs to avoid the many myths and distortions in popular conceptions of brain and genetics. It should instead focus on integrating research with practice to create useful evidence that illuminates the brain and genetic bases as well as social and cultural influences on learning and teaching. Scientists and educators need to collaborate to build a strong research foundation for analyzing the “black box” of biological and cognitive processes that underpin learning.  相似文献   

Amplitude envelope perception, phonology and prosodic sensitivity in children with developmental dyslexia     

Usha Goswami  Danielle Gerson  Luisa Astruc 《Reading and writing》2010,23(8):995-1019

Here we explore relations between auditory perception of amplitude envelope structure, prosodic sensitivity, and phonological awareness in a sample of 56 typically-developing children and children with developmental dyslexia. We examine whether rise time sensitivity is linked to prosodic sensitivity, and whether prosodic sensitivity is linked to phonological awareness. Prosodic sensitivity was measured by two reiterant speech tasks modelled on Kitzen (2001). The children with developmental dyslexia were significantly impaired in the reiterant speech tasks and in the phonological awareness tasks (onset and rime awareness). There were significant predictive relations between basic auditory processing of amplitude envelope structure (in particular, rise time), prosodic sensitivity, phonological awareness, reading, and spelling. The auditory processing difficulties that characterise children with developmental dyslexia appear to impair their sensitivity to phrase-level prosodic cues such as metrical structure as well as to phonology, but in this study phonological and prosodic sensitivity made largely independent contributions to reading.  相似文献   

Neuroscience, education and special education     

Usha Goswami 《British Journal of Special Education》2004,31(4):175-183

The discipline of neuroscience draws from the fields of neurology, psychology, physiology and biology, but is best understood in the wider world as 'brain science'. Of particular interest for education is the development of techniques for 'imaging' the brain as it performs different cognitive functions. Cognitive neuroimaging has already led to advances in understanding some of the basic functions involved in learning and raised implications for education and special education in particular. For example, neuroimaging has enabled scientists to study the very complex processes underpinning speech and language, thinking and reasoning, reading and mathematics. In this article, Professor Usha Goswami of the University of Cambridge Faculty of Education first reviews basic information on brain development. She provides a brief introduction to the tools used in neuroimaging then considers recent findings from neuroscience that seem relevant to educational questions. Professor Goswami uses this review to suggest particular ways in which neuroscience research could inform special education. In its closing sections, this article provides authoritative perspectives on some of the 'neuromyths' that seem to have taken root in the popular imagination and argues for increased dialogue, in the future, between the disciplines of neuroscience and education.  相似文献   

Phonological development and reading by analogy: what is analogy,and what is it not?     

Usha Goswami 《Journal of Research in Reading》1995,18(2):139-145

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Correction to: Basic Auditory Processing Skills and Phonological Awareness in Low-IQ Readers and Typically Developing Controls     

Sarah Kuppen  Martina Huss  Tim Fosker  Natasha Fegan  Usha Goswami 《Scientific Studies of Reading》2013,17(6)

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Phosphorus Compounds: Their Discovery in Biological World     

Lakshna Mahajan  Shweta Saxena  P. Usha Sarma 《Indian journal of clinical biochemistry : IJCB》2018,33(3):243-245

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Host pathogen interactions in allergic and invasive fungal diseases: Diagnostic and therapeutic implications     

P. Usha Sarma 《Indian journal of clinical biochemistry : IJCB》2001,16(2):137-139

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Challenges in prevention,diagnosis and therapy of emerging fungal diseases. Aspergillosis: A case study     

P. Usha Sarma  P V G K Sarma  Taruna Madan 《Indian journal of clinical biochemistry : IJCB》2000,15(1):43-50

Diseases caused by pathogenic filamentous fungi, are an emerging threat to public health in the wake of increasing incidence of HIV and tuberculosis. At this point, discovery and development of fungal therapeutics and diagnostics are serious challenges for biomedical researchers. Recent technological advances in genomics and proteomics offer great scope for development of preventive and therapeutic measures for fungal diseases.Aspergillus, one of the medically important filamentous pathogenic fungi causes a wide spectrum of clinical disorders ranging from allergic aspergillosis to systemic invasive aspergillosis. Increase in incidence of drug resistance and the cytotoxic effects are two serious limitations of the antifungal drugs presently in use. This is primarily due to lack of understanding of biological mechanisms operative in these fungi. Today, it is possible to understand the biological mechanisms of the fungus for its colonisation, survival and invasion of the host. Future developments based on such leads can result in development of precise and specific diagnostic, therapeutic and preventive measures for a wide clinical spectrum of fungal diseases.  相似文献   

β-Adrenoreceptor Agonist Isoproterenol Alters Oxidative Status,Inflammatory Signaling,Injury Markers and Apoptotic Cell Death in Myocardium of Rats     

Santosh K. Shukla  Suman B. Sharma  Usha R. singh 《Indian journal of clinical biochemistry : IJCB》2015,30(1):27-34

Sustained high levels of circulating catecholamines are reported to induce cardiotoxicity. Isoproterenol (ISP), a synthetic catecholamine has been widely employed to induce myocardial injury, though the role of inflammation and apoptosis is not well established. This study was designed to investigate the underlying mechanism of oxidative damage, inflammatory signaling, cell death in ISP induced myocardial infarction in rats. Wistar albino rats were divided in two groups: group I (sham control) and group II (ischemic control). ISP (85 mg/kg, s.c.) was administered at an interval of 24 h to group II for two consecutive days. On day third, after 48 h of the first injection of ISP, blood was collected from retro orbital plexus of rat eyes to estimate the biochemical parameters. Glutathione (GSH) and superoxide dismutase (SOD) were measured for antioxidant status. Similarly, malondialdehyde (MDA) was measured as an index of lipid peroxidation. Cardiac markers (SGOT, CK-MB, TropI and LDH) and pro-inflammatory cytokines (IL-6, CRP and TNF-α) were also estimated in ISP-induced rats. At the end of experiments animals were sacrificed for histopathological studies. GSH and SOD showed significant decrease after ISP challenge as compared to sham (control) group (p < 0.01) while MDA level, increased significantly (p < 0.01). ISP, also increased the level of cardiac markers and markers of inflammation significantly (p < 0.01), which was further verified by histopathological studies of the heart tissues. The study confirmed that ISP causes detrimental changes in the myocardium by altering cardiac and inflammatory markers, which leads to severe necrosis. The deleterious effects produced by ISP substantiate its suitability as a novel animal model for evaluation of cardioprotective agents/drugs.  相似文献   

Multiple Biomarkers to Assess the Pathophysiological State in Critically Ill Patients with Sepsis     

Prashanth Ashok Kumar  Usha Anand 《Indian journal of clinical biochemistry : IJCB》2016,31(3):310-314

Sepsis is associated with various metabolic derangements as a consequence of inflammatory response, ischemia and oxidative stress. Four parameters of relevance are procalcitonin (PCT), ischemia modified albumin (IMA) pH and lactate. The study was carried out to highlight the concomitant occurrence of sepsis, ischemia and lactic acidosis, all of which could have deleterious effects on organ function. 26 critically ill patients with a provisional diagnosis of sepsis were the test subjects. The control group had 25 apparently healthy volunteers. PCT, lactate and IMA were assayed. PCT was estimated on an automated analyser using electro-chemiluminescence. Lactate and pH were estimated on a blood gas analyzer. Serum IMA was estimated spectrophotometrically by Albumin Cobalt Binding Test. Statistical tools like students ‘t’ test and Venn diagram were employed to depict the outcome of the study. All critically ill patients had significantly higher IMA levels (0.96746 ± 0.73407) as compared to the control group (0.00728 ± 0.00895) with a p value of <0.0001. The Venn diagram was used to depict the finding that all 26 test subjects had elevated levels of IMA, of which PCT was elevated in 22 and lactate in 20. Both PCT and lactate were abnormal in 17 patients. The most significant observation was that all critically ill patients, irrespective of the presence of sepsis or lactic acidosis had elevated levels of IMA which is clearly indicative of the ubiquitous presence of oxidative stress. The Venn diagram is an elegant representation of the concurrent multiple pathophysiological processes which occur in critically ill patients.  相似文献